Cardio-protective determinants are conserved in aged human myocardium after ischemic preconditioning
نویسندگان
چکیده
منابع مشابه
Ischemic preconditioning of myocardium.
Preconditioning of the myocardium with short episodes of sublethal ischemia will delay the onset of necrosis during a subsequent lethal ischemic insult. Ischemic preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel...
متن کاملIschemic preconditioning is not cardioprotective in senescent human myocardium.
BACKGROUND Cellular and functional changes secondary to aging could impair myocardial tolerance to ischemia and affect the heart's response to ischemic preconditioning. METHODS We investigated the impact of cardiac aging on preconditioning in right atrial trabeculae of adult patients (< or = 55 years) and senescent patients (> or = 70 years) with coronary artery disease. Specimens were subjec...
متن کاملProtective responses in the ischemic myocardium.
Acute coronary syndromes and heart failure arising as a consequence of ischemic injury to the myocardium account for a large proportion of all hospital admissions and of all causes of death in industrialized nations. Medical and surgical management of these conditions consumes enormous resources each year, but current therapeutic measures fall far short of reducing death and disability from isc...
متن کاملPlatelet-derived microvesicles are involved in cardio-protective effects of remote preconditioning.
The ischemia-protective mechanism of remote precondition has been a mystery for a long time. Little was known about details of the inter-organ cardio-protective. Microvesicles, also known as microparticles (MPs), are small membrane-vesicles budding from the plasma membrane of cell. Recent studies have indicated MPs to be an important messenger in various biological processes. Our research mainl...
متن کاملProtective Effect of Ischemic Preconditioning via ''Imported'' Nitric Oxide Synthase Endothelial Progenitor Cells Are Rapidly Recruited to Myocardium and Mediate
Masaaki Ii, Hiromi Nishimura, Atsushi Iwakura, Andrea Wecker, Elizabeth Eaton, Takayuki Activity Protective Effect of Ischemic Preconditioning via ''Imported'' Nitric Oxide Synthase Endothelial Progenitor Cells Are Rapidly Recruited to Myocardium and Mediate Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the A...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2003
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(03)01342-5